Samuel Perkins was born 22 November 1699 in Topsfield, Essex County, Massachusetts, United States to Thomas Perkins (c1659-1719) and Sarah Wallis (1658) and died 24 February 1764 of unspecified causes. He married Margaret Towne (1700-1757) 22 August 1723 in Topsfield, Essex County, Massachusetts, United States. He married Martha Gould (1709-1771) 17 September 1761 .
Children
| Name | Birth | Death | Joined with |
| Hannah Perkins (1720-1807) | |||
| Thomas Perkins (1724) | |||
| Margaret Perkins (1728) | |||
| Samuel Perkins (-) | |||
| Mary Perkins (1733) | |||
| Archelaus Perkins (1736) | |||
| Sarah Perkins (1737) | |||
| Name | Birth | Death | Joined with |
| Evan Asa Perkins | Abigail Cleveland | ||