Samuel Pierson, Sr. was born circa 1663 in Branford, New Haven County, Connecticut to Thomas Pierson (1634-1701) and Maria Harrison (1734-1701) and died 19 March 1730 Newark, Essex County, New Jersey of unspecified causes. He married Mary Harrison (1661-1732) 1684 in Essex County, New Jersey.
Children
| Name | Birth | Death | Joined with |
| James Pierson (1685-1749) | |||
| Joseph Pierson (1693-1759) | |||
| Samuel Pierson (1698-1781) | 1698 Orange, Essex County, New Jersey | 6 November 1781 Orange, Essex County, New Jersey | Mary Sargeant (1700-1779) |
| Jemima Pierson (1702-) | |||
| Daniel Pierson (1703-1777) | |||
| Caleb Pierson (1705-1743) | |||
| Hannah Pierson (1715-1794) | |||
Siblings
| Name | Birth | Death | Joined with |
| Thomas Pierson (1653-1722) | |||
| Mary Pierson (1662-1709) | |||
| Samuel Pierson (1663-1730) | 1663 Branford, New Haven County, Connecticut | 19 March 1730 Newark, Essex County, New Jersey | Mary Harrison (1661-1732) |
| Eliza Pierson (1667-) | |||
| Abigail Pierson (1669-) | |||
| Hannah Pierson (1674-1705) | |||