Samuel Sampson was born circa 1646 in Duxbury, Plymouth County, Massachusetts to Abraham Sampson (1614-1686) and Esther Nash (1638-1735) and died 1675 Duxbury, Plymouth County, Massachusetts of unspecified causes. He married Hester Delano (1638-1733) 1660 in Duxbury, Plymouth County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Samuel Sampson (1670-1744) | |||
| Mary Sampson (1670-1706) | |||
| Elizabeth Sampson (1672-) | |||
| Ichabod Sampson (1672-) | |||
Siblings
| Name | Birth | Death | Joined with |
| Samuel Sampson (1646-1675) | 1646 Duxbury, Plymouth County, Massachusetts | 1675 Duxbury, Plymouth County, Massachusetts | Hester Delano (1638-1733) |
| Elizabeth Sampson (1648-1708) | 1648 Duxbury, Plymouth County, Massachusetts | 11 December 1708 Duxbury, Plymouth County, Massachusetts | Philip Delano (1638-1708) |
| Mary Sampson (1652-1674) | |||
| George Sampson (1655-1739) | |||
| Mary Sampson (1657-1675) | |||
| Abraham Sampson (1658-1725) | 1658 Duxbury, Plymouth County, Massachusetts | 16 November 1725 Duxbury, Plymouth County, Massachusetts | Lorah Standish (1660-1725) |
| Judith Sampson (1659-1727) | |||
| Isaac Sampson (1660-1726) | 1660 Duxbury, Plymouth County, Massachusetts | 3 September 1726 Plympton, Plymouth County, Massachusetts | Lydia Standish (1662-1749) |
| Sarah Sampson (1663-) | |||