Thankful Brigham was born 7 May 1765 in Marlborough, Middlesex County, Massachusetts to George Brigham (1730-1808) and Mary Bragg (1735-1822) and died 14 December 1824 Marlborough, Middlesex County, Massachusetts of unspecified causes. She married Daniel Brigham (1760-1818) 29 August 1782 in Stow, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Mary Brigham (1783-) | |||
| George Brigham (1784-1824) | |||
| Daniel Brigham (1785-) | |||
| Dexter Brigham (1786-1838) | |||
| Elizabeth Brigham (1788-1828) | |||
| Thankful Brigham (1791-1831) | |||
| William Brigham (1793-1833) | |||
| Winslow Brigham (1795-1835) | |||
| Amariah Brigham (1797-1825) | |||
| Freeman Brigham (1800-1860) | |||
| Charlotte Brigham (1802-1862) | |||
| Harriet Brigham (1804-1889) | |||
| Laura Ann Brigham (1807-1882) | |||
Siblings
| Name | Birth | Death | Joined with |
| Phineas Brigham (1754-1755) | |||
| George Brigham (1756-) | |||
| Phineas Brigham (1757-1813) | 7 October 1757 Marlborough, Middlesex County, Massachusetts | 17 March 1813 Eaton, Madison County, New York | Susanna Howe (1764-1813) |
| Timothy Brigham (1759-) | |||
| Louisa Brigham (1760-1771) | |||
| Ashbel Brigham (1762-1771) | |||
| Mary Brigham (1763-1771) | |||
| Thankful Brigham (1765-1824) | 7 May 1765 Marlborough, Middlesex County, Massachusetts | 14 December 1824 Marlborough, Middlesex County, Massachusetts | Daniel Brigham (1760-1818) |
| Zerviah Brigham (1767-1771) | |||
| Samuel Brigham (1769-1771) | |||
| Stephen Brigham (1771-1771) | |||
| Samuel Brigham (1772-) | |||
| Maru Louisa Brigham (1773-1775) | |||
| Stephn Brigham (1774-1775) | |||
| William Brigham (1779-) | |||