Thankful Howe was born 15 December 1703 in Sudbury, Middlesex County, Massachusetts to David Howe (1674-1759) and Hepzibah Dearth (1680-1769) and died 25 January 1766 Hopkington, Middlesex County, Massachusetts of unspecified causes. She married Peter Howe (1696-1766) 9 April 1723 in Sudbury, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Nehemiah Howe (1720-1777) | 13 January 1720 Marlborough, Middlesex County, Massachusetts | April 1777 Poultney, Rutland County, Vermont | Beulah Wheeler (1723-1778) |
| Peter Howe (1724-1780) | |||
| Thankful Howe (1726-1795) | |||
| Lois Howe (1729-) | |||
| Jothan Howe (1733-) | |||
| Phineas Howe (1735-1807) | 22 October 1735 Hopkinton, Middlesex County, Massachusetts | 19 September 1807 Hopkington, Middlesex County, Massachusetts | Susannah Goddard (1742-1837) |
| Hepzibah Howe (1741-) | |||
| Nehemiah Howe (1747-1825) | |||
Siblings
| Name | Birth | Death | Joined with |
| Thankful Howe (1703-1766) | 15 December 1703 Sudbury, Middlesex County, Massachusetts | 25 January 1766 Hopkington, Middlesex County, Massachusetts | Peter Howe (1696-1766) |
| Hepzibah Howe (1706-1792) | 1 October 1706 Sudbury, Middlesex County, Massachusetts | 15 April 1792 Shrewsbury, Worcester County, Massachusetts | Cyprian Keyes (1706-1802) |
| Eliphalet Howe (1710-1785) | |||
| Israel Howe (1712-1748) | |||
| Ruth Howe (1714-1809) | |||
| David Howe (1717-1802) | |||
| Ezekiel Howe (1720-1796) | |||