Thomas Keyes was born 8 February 1674 in Sudbury, Middlesex County, Massachusetts to Elias Keyes (1643-1677) and Sarah Blandford (1642-1724) and died 25 August 1742 Marlborough, Middlesex County, Massachusetts of unspecified causes. He married Elizabeth Howe (1675-1764) 23 January 1698 in Marlborough, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| David Keyes (1699-1720) | |||
| Jonathan Keyes (1702-1778) | |||
| Cyprian Keyes (1706-1802) | 15 September 1706 Marlborough, Middlesex County, Massachusetts | 18 June 1802 Shrewsbury, Worcester County, Massachusetts | Hepzibah Howe (1706-1792) |
| Dinah Keyes (1710-1784) | 4 March 1710 Marlborough, Middlesex County, Massachusetts | 15 December 1784 Marlborough, Middlesex County, Massachusetts | John Weeks (1706-1787) |
| Thomas Keyes (1713-1735) | |||
| Henry Keyes (1699-1757) | |||
Siblings