William Clayton was born 8 December 1632 in Chichester, Sussex, England to William Clayton (c1605-1658) and Joan Smith (c1610-1644) and died 1689 Chester County, Pennsylvania, United States of America of unspecified causes. He married Prudence Lanckford (c1633-) 7 November 1653 in Sussex, England.
Children
| Name | Birth | Death | Joined with |
| Prudence Clayton (1657-1728) | |||
| Joseph Clayton (1660-) | |||
| Honour Clayton (1662-aft1715) | 18 March 1662 Rumboldswyke Parish, Sussex, England, United Kingdom | 24 December 1737 Nottingham, Chester County, Pennsylvania, United States | James Browne (1656-1715) |
| William Clayton (1665-1727) | |||
| Elizabeth Clayton (1665-1665) | |||
| Mary Jane Clayton (1665-1725) | |||
| Hannah Clayton (1667-1668) | |||
Siblings
| Name | Birth | Death | Joined with |
| William Clayton (1632-1689) | 8 December 1632 Chichester, Sussex, England | 1689 Chester County, Pennsylvania, United States of America | Prudence Lanckford (c1633-) |