William Spencer was born circa 1601 in Stotfold, Bedfordshire, England, United Kingdom to Gerard Spencer (c1576-1625) and Alice Whitbread (1571-1628) and died 26 May 1640 Haddam, Middlesex County, Connecticut, United States of unspecified causes. He married Agnes Harris (1604-1680) 1632 .
|Offspring of William Spencer and Agnes Harris (1604-1680)|
|Elizabeth Spencer (c1633-1680)|
|Sarah Spencer (1636-1691)||20 April 1636 Cambridge, Massachusetts, United States||3 November 1691 Simsbury, Connecticut, United States||John Case (1616-1704)|
|Samuel Spencer (c1639-1716)|