Zachariah Weston, Sr. was born 16 December 1690 in Plympton, Plymouth County, Massachusetts to Edmund Weston (1660-1727) and Rebecca Soule (1659-1732) and died 27 September 1763 Plympton, Plymouth County, Massachusetts of unspecified causes. He married Mehitable Shaw (1694-1764) 1715 in Plymouth, Plymouth County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Jonathan Weston (1717-1763) | |||
| Mehitable Weston (1719-1776) | |||
| Zachariah Weston (1719-1726) | |||
| James Weston (1720-1786) | |||
| Zachariah Weston (1728-1794) | 21 December 1728 Plympton, Plymouth County, Massachusetts | 9 April 1794 Middleborough, Plymouth County, Massachusetts, United States | Rebeckah Standish (1732-1769) Sarah Pomeroy (1734-1795) |
| Rebecca Weston (1730-1807) | |||
Siblings
| Name | Birth | Death | Joined with |
| Nathan Weston (1689-1754) | 8 February 1689 Plymouth, Plymouth County, Massachusetts | 11 October 1754 Plympton, Plymouth County, Massachusetts | Desire Standish (1689-1766) |
| Zachariah Weston (1690-1763) | 16 December 1690 Plympton, Plymouth County, Massachusetts | 27 September 1763 Plympton, Plymouth County, Massachusetts | Mehitable Shaw (1694-1764) |
| Rebecca Weston (1693-1782) | |||
| John Weston (1695-1723) | |||
| Edmond Weston (1697-1773) | |||
| Benjamin Weston (1701-1773) | |||